• Bacterial infection in zebrafish

    Mycobacterium marinum bacteria (red) have been micro-injected into the blood vessels (green) of a zebrafish embryo. Within several days the infection will cause a disease that develops similar hallmarks as human tuberculosis.

    Image by Erica Benard, Institute of Biology, Leiden University

  • Bone staining in zebrafish

    Alizarin red staining of a juvenile zebrafish labelling calcified tissues (bones).

    Image by Quang Tien PHAN and Georges Lutfalla, CNRS.

  • Dissemination of mycobacterial infection

    Dissemination of Mycobacterium marinum infection (red fluorescent) from the hindbrain to the trunk and tail fin of a zebrafish larva.

    Image by Vincenzo Torraca, Leiden University.

  • Inflammation around Staphylococcus aureus abscess

    The zebrafish NF-κB reporter line for inflammation (green) shows activation of inflammatory pathway around an abscess formed by S. aureus (red).

    Image by Nelly Wagner, University of Sheffield

  • Inflammation in medaka fish

    Medaka fish (Oryzias latipes) reporter line for inflammation (green) after overexpression of an inflammatory molecule (red).

    Image by Paola Kuri, EMBL

  • Inflammation in notochord triggered by LPS from E. coli

    Liopopolysaccharide (LPS) derived from the cell wall of E. coli triggers inflammation after injecting into the notochord. Green cells represent neutrophils of the mpx:GFP transgenic zebrafish larva.

    Image by Quang-Tien PHAN, CNRS.

  • Interaction between zebrafish neurons and glial cells

    Co-culture of neurons (red) and glial cells (green) derived from  zebrafish transgenic lines.

    Image by Gabriella Passoni, INRA.

  • Phagocytosed Staphylococcus aureus in zebrafish embryo

    Live imaging shows the phagocytosis of Staphylococcus aureus bacteria (labelled with green fluorescent protein) by immune cells after injection into the blood of a zebrafish embryo.

    Image by Justyna Serba, University of Sheffield.

  • Staphylococcus aureus infection in zebrafish embryo

    Staphylococci are the main cause of hospital-acquired infections. Transparent zebrafish embryos are very useful to study the intracellular stages of Staphylococcus aureus infection. In the image fluorescent dyes reveal whether the pathogen resides within acidified (red) compartments of immune cells where it can be eliminated or in non-acidified (green) environments where it can grow .

    Image by Justyna Serba, University of Sheffield.

  • Viral infection in zebrafish

    IHNV virus (red) infects and destructs blood vessels (green) in the head of a zebrafish embryo and thereby can spread to adjacent tissues (blue). Whole-body imaging of this infection in zebrafish is used as a model for hemorrhagic viral disease.

    Image by Nuho Palha, Institut Pasteur, published in PLoS Pathogens 2011

     

  • Wound healing and inflammation

    A wound at the tail tip of a zebrafish embryo attracts two types of immune cells: macrophages (red) and neutrophils (green). A new transgenic zebrafish line is a powerful models to study the behavior of these cells during inflammation.

    Image by Steve Renshaw, University of Sheffield, published in Thrombosis and Haemostasis 2011

  • XRay tomography of adult zebrafish

    XRay tomography of an adult zebrafish with colored individual vertebrae.

    Image by Quang Tien PHAN and Georges Lutfalla, CNRS

  • Zebrafish leukocytes

    Zebrafish leukocytes derived from the kidney stained with May-Grünwald/Giemsa dye demonstrating the similar morphology to human leukocytes.

    Image by Elina Aleksejeva, INRA

European funding supports the training of young scientists in the FishForPharma network