FishForPharma congratulates Sylwia Tyrkalska on being the first of our Marie Curie fellows to obtain her PhD degree. She successfully defended her thesis “Molecular and functional characterization of zebrafish Gbp4: a new inflammasome component ” on the 27th of July 2015 at the University of Murcia. We wish Sylwia all the best for her future career.
Ruben Marin-Juez, our former postdoctoral fellow at ZF-Screens, as part of his work within the FishForPharma consortium, has co-authored a work in collaboration with the UL in which the zebrafish was used to study the Trl2 and Tlr5 signaling pathways. As part of this study, the authors used the zebrafish as a whole animal model to identify sets of specific genes triggered upon Tlr2 and Tlr5 stimulation.
FishForPharma is proud to announce its final dissemination Symposium "Zebrafish models of host-pathogen interaction". This event will take place on the 5th of September as a Special Interest Symposium at the EMBO 2015 meeting in Birmingham. The Symposium will bring a varied selection of talks on bacterial, viral and parasite infection studies by speakers representing the FishForPharma consortium and invited keynote speakers Serge Mostowy (Imperial College London) and Andres Floto.(University of Cambridge).
After finishing his two years Marie Curie fellowship in the FishForPharma consortium, Julien Rougeot has now found a new post-doc position at the Radboud University in Nijmegen where he will continue to work with the zebrafish model and build further on his expertise in genomics. We thank Julien for his contribution to our project and the very pleasant collaboration with all of us. We wish you all the best in your future carreer.
The group of Georges Lutfalla (partner 2) contributed to an elegant study in Nature Communications showing the critical role of macrophages in controlling how Hematopoietic Stem/Progenitor Cells (HSPCs) emerge from endothelial cells of the dorsal aorta to initiate definitive haematopoiesis.
Sylwia Tyrkalska is coauthor of a publication that establishes a new role for Md1/Rp105 receptor complex in antiviral immunity besides it widely known involvement in the negative regulation of LPS/TLR4 signaling. Genetic inhibition of zebrafish Md1 and Rp105 reveals that Md1 or Rp105 deficiency impairs the expression of genes encoding pro-inflammatory and antiviral molecules, leading to increased susceptibility to viral infection.
Vincenzo Torraca (Leiden University) is first author of a publication that establishes a direct link between the host CXCR3/CXCL11 chemokine signaling and the development of mycobacterial infection. In a Cxcr3 zebrafish mutant, macrophage recruitment to mycobacterial infection is attenuated and this reduced the expansion and seeding of granulomas by Mycobacterium marinum. Targeting the CXCR3 pathway might therefore be explored as a host-directed therapeutic strategy for treatment of tuberculosis.
ZF-Pharma, a daughter company of ZF-Screens (Partner 9) has now added an automated toxicology screening pipeline to its portfolio. They offer rapid teratogenetic and acute toxic compound screening in the zebrafish larvae model.