Fraser Cunningham, our fellow at GSK, in collaboration with other partners from the consortium (UL and ZF-screens) published a paper that offers a new tool for testing drug uptake in the zebrafish larvae which combines nanoliter-sampling from the yolk using a micro-needle, followed by mass spectrometric analysis. This uptake assay together with antibacterial activity assays in the zebrafish model could strengthen the conventional disease screening pipeline.
Ruben Marin-Juez, a former fellow at ZF-Screens, based on his work within the consortium published a paper in which a zebrafish model was developed to study insulin metabolism and its associated disorders. The established zebrafish model for hyperinsulinemia demonstrated its suitability for discovery of novel regulators of insulin resistance. This work is also relevant to the study of infectious diseases, since diabetes is known as a risk factor for tuberculosis.
Ruben Marin-Juez (ZF-Screens) is the corresponding author of this publication about an established model for glut12 deficiency in zebrafish. This model assists in the understanding of the role of insulin-regulated glucose transporters (GLUTs) and the development of cardiomyopathies-associated metabolic pathologies such as type 2 diabetes and insulin resistance.
Collaborators at EMBL (Partner 7) found that exposure of zebrafish to UV radiation at the levels that would cause sunburn in humans induces inflammation characterized by systemic induction of proinflammatory cytokines with leukocytes as an important component of this systemic response. Increased levels of IL-1β counteract the lethal effect of high doses of UV.
Obesity and metabolic syndrome-related diseases are becoming important medical challenges and Non-Alcoholic Fatty Liver Disease (NAFLD) is a manifestation of these altered conditions in the liver, where inflammation appears to be a factor that is tightly connected to its evolution. Authors from CSIC (Partner 5) investigated this disease in zebrafish.
In this work published by CSIC (Partner 5) zebrafish is used to increase our knowledge of the global transcriptome associated with sepsis, the most common cause of death in intensive care units due to an aggressive inflammatory response, as well as a yet unclear response of LPS tolerance.
Lili Zhang (INSERM) was present at the “Fête de la Science” on October 11 in Nimes, France. This event is held every year to give the public the possibility to meet with scientists, and learn more about many different aspects of scientific research. In Nimes, the INSERM research lab U1047 participated with an exposition, including posters, a video demo, and live zebrafish embryos and nematodes under a dissecting microscope, to inform the public about the use of animal models, microbiology, infectious disease studies, and clinical research. Lili, prepared a poster to highlight the zebrafish for biomedical research, and the FishForPharma project.
University of Sheffield, together with other collaborators, published a paper in Science on the evolutionarily conserved role for nerve growth factor b - tropomyosin-related kinase receptor A signaling in controlling vertebrate immunity during Staphylococcus aureus infection.