Authors of this paper (CSIC and UL) take advantage of the use of zebrafish larvae in the study of viral hemorrhagic diseases, focusing on the interaction between viruses and host cells to increase the potential for the discovery of new therapeutic targets against diverse viral diseases.
Check out the special issue of Disease Models & Mechanisms "Spotlight on zebrafish: translational impact" with contributions from FishForPharma fellows Tien Phan and Vincenzo Torraca
In this paper, where one of the FishForPharma principal investigators, George Lutfalla (CNRS) is a co-author, an experimental protocol is developed to assess the in vivo drug activity infection on Mycobacterium abscessus, one of the most intrinsically drug-resistant mycobacterial specie.
CSIC’s recent publication describes c3 genes in the zebrafish genome and suggests important roles in the complement system acting as a first line of defense.
In this paper, where one of the FishForPharma fellows, Nelly Wagner is a co-author, a combination of animal models were used to study the spread of bacteria between organs during an infection and the resulting effect of antibiotic intervention.
George Lutfalla (CNRS) and his collaborators adapted the zebrafish embryo as a tractable infection model to study, at a spatiotemporal level, the physiopathology of Mycobacterium abscessus infection, responsible for severe pulmonary infections in cystic fibrosis patients, and describe their results in this paper.
A collaboration between a FishForPharma partner, CNRS with other groups resulted in this publication in which the authors describe that map9 is a crucial factor in early zebrafish development.
FishForPharma partners at Institute Pasteur and INRA published this paper overviewing the zebrafish model that offers a fascinating window to observe how viral infections unravel in a vertebrate in real time.