As highlighted in the Leiden University news, the group of Annemarie Meijer published in Cell Host & Microbe that DRAM1 is a important modulator of autophagy that functions downstream of pathogen recognition by the TLR-MYD88-NF-κB pathway in controlling infection with intracellular mycobacteria.
One of our fellows, Sylwia Tyrkalska from University of Murcia is a co-author on a paper publishing results suggesting that new therapeutic targets involved in Tnfa Signaling could provide innovative approaches to the management of skin inflammatory disorders such as psoriasis and lichen planus.
INRA, a partner within FishForPharma, in collaboration with Leiden University, published a study that provides a useful reference set for the analysis of host-virus interactions in zebrafish and highlights the differences between protective and nonprotective antiviral innate responses.
GSK, one of the partners in FishForPharma, will host a conference ‘Towards New Therapeutics for Diseases of the Developing World’ between 11-13 May, 2014 in Tres Cantos, Madrid, Spain. The meeting will focus on medicinal chemistry approaches to making new medicines, highlighting the latest developments in tackling malaria, TB, and kinetoplastid diseases. Registration deadline is 25 April, 2014.
The Wikipedia article on zebrafish has been updated with a new section that explains the advantages of zebrafish models for human infectious disease research and drug discovery, and also it is linked to the goals of FishForPharma in this field.
Phil Elks, a researcher at Leiden University, won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens. This is a joint paper of two partners from the FishForPharma network, Leiden University and Sheffield University, showing that activation of hypoxia signaling protects against mycobacterial infection.
Two fellows of the FishForPharma network at INRA, Elina Aleksejva and Gabriella Passoni, are co-authors of this review paper on the conservation of the interferon system and its importance in the innate antiviral responses in fish.
Another joint paper of Wageningen and Leiden Universities showing a role for the non-mammalian Toll-like receptor 20 in the response to parasitic infections