Publications

  • Antiviral Innate Immune Response in Fish

    Antiviral Innate Immune Response in Fish

    In this review, by comparing the interferon (IFN) system between teleosts and mammals, the authors focus on its evolution in vertebrates.

    Langevin C, Aleksejeva E, Passoni G, Palha N, Levraud JP, Boudinot P. J Mol Biol. 2013 Dec 13;425(24):4904-20. doi: 10.1016/j.jmb.2013.09.033. Epub 2013 Sep 27.

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  • Role of plasmid pC3 in stress tolerance in Burkholderia cepacia complex

    Role of plasmid pC3 in stress tolerance in Burkholderia cepacia complex

    In this study the authors provide evidence demonstrate the prevalence of plasmid pC3 among Bcc isolates and its role in conferring resistance to multiple environmental stress factors.

    Agnoli K, Frauenknecht C, Freitag R, Schwager S, Jenul C, Vergunst A, Carlier A, Eberl L. Appl Environ Microbiol. 2013 Dec 13. [Epub ahead of print]

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  • Identification and functional characterization of nonmammalian Toll-like receptor 20

    Identification and functional characterization of nonmammalian Toll-like receptor 20

    In this paper, TLR20, so far with unknown function in teleost fish, has been studied in two closely related fish species, zebrafish and common carp, indicating a role in the immune response to protozoan parasites has been indicated.

    Pietretti D, Scheer M, Fink IR, Taverne N, Savelkoul HF, Spaink HP, Forlenza M, Wiegertjes GF. Immunogenetics. 2013 Dec 11. [Epub ahead of print]

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  • Accessory molecules for Toll-like receptors in Teleost fish

    Accessory molecules for Toll-like receptors in Teleost fish

    This paper discusses the presence and conservation of accessory proteins, important for the biosynthesis and activation of TLR molecules in zebrafish and in common carp, thus may help refine studies on the biological activity of TLRs in fish.

    Pietretti D, Spaink HP, Falco A, Forlenza M, Wiegertjes GF. Mol Immunol. 2013 Dec;56(4):745-56. doi:10.1016/j.molimm.2013.07.012. Epub 2013 Aug 16.

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  • IL-22 as a key regulator of inflammatory homeostasis in zebrafish

    IL-22 as a key regulator of inflammatory homeostasis in zebrafish

    In this article, for the first time, data is presented on the biological function of IL-22 in a non-mammalian species, with a special focus on its immunomodulatory role.

    Costa MM, Saraceni PR, Forn-Cuní G, Dios S, Romero A, Figueras A, Novoa B. Dev Comp Immunol. 2013 Dec;41(4):746-55. doi: 10.1016/j.dci.2013.08.021. Epub 2013 Aug 30.

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  • Real-time imaging and genetic dissection of host–microbe interactions in zebrafish

    Real-time imaging and genetic dissection of host–microbe interactions in zebrafish

    This review describes new insights in the processes of host defence mechanisms, such as the innate immune recognition , myeloid defence mechanisms, immunometabolism and the autophagic destruction machinery, that are predicted to be relevant for biomedical research.

    Meijer AH, van der Vaart M, Spaink HP. Cell Microbiol. 2013 Nov 5. doi: 10.1111/cmi.12236. [Epub ahead of print]

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  • Stabilization of Hif-1α as a potential target for therapeutic intervention against tuberculosis.

    Stabilization of Hif-1α as a potential target for therapeutic intervention against tuberculosis.

    In this paper we show that in vivo manipulation of a host-signaling pathway aids the host in combatting mycobacteria infection, identifying hypoxic signaling as a potential target for future therapeutics against TB.

    Elks PM, Brizee S, van der Vaart M, Walmsley SR, van Eeden FJ, et al. (2013) PLoS Pathog 9(12): e1003789. doi:10.1371/journal.ppat.1003789

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  • MicroRNA expression during bacterial infection in zebrafish

    MicroRNA expression during bacterial infection in zebrafish

    In this paper we identify infection-inducible microRNA families that are conserved between zebrafish and human and show that one of these, the miR-146 family, affects apolipoprotein gene expression during infection.                                                                             

    Ordas A, Kanwal Z, Lindenberg V, Rougeot J, Mink M, Spaink HP, Meijer AH. BMC Genomics. 2013 Oct 10;14(1):696.

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  • Robotic injection of zebrafish embryos for high-throughput screening in disease models

    Robotic injection of zebrafish embryos for high-throughput screening in disease models

    In this article detailed protocols are presented for the robotic injection of zebrafish embryos at very high accuracy and speed opening up new avenues for the use of zebrafish larvae for large compound screens in the search for new medicines. 

    Spaink HP, Cui C, Wiweger MI, Jansen HJ, Veneman WJ, Marín-Juez R, de Sonneville J, Ordas A, Torraca V, van der Ent W, Leenders WP, Meijer AH, Snaar-Jagalska BE, Dirks RP, (2013) Methods, PMID: 23769806

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  • Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish

    Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish

    In this review article we give an overview of the pattern recognition receptors that identify invading microbes and describe the innate immune effector mechanisms that they activate in zebrafish embryos.

    van der Vaart M, Spaink HP, Meijer AH (2012) Advances in Hematology, article ID 159807

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European funding supports the training of young scientists in the FishForPharma network